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apalutamide will decrease the level or influence of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicine that happen to be CYP3A4 substrates may end up in decrease exposure to those drugs.one. Choose the initial "Livel